The world is a complex system, and understanding it scientifically requires advanced computational resources and approaches. Engineers design the most powerful computers on Earth in order to model and simulate physical systems such as global climate, the expansion of the universe, and the behavior of matter at an atomic level. But today, high performance scientific computing means more than just supercomputers running numerical models, expanding to large-scale data analysis, AI and machine learning, visualization, and distributed and heterogeneous hardware systems.

UChicago CS researchers are changing the face of high performance computing (HPC), creating new computing paradigms at scale for understanding physical, biological, social, and ecological systems and answering the most significant questions facing society. Faculty lead efforts to apply the latest AI and data science approaches for scientific discovery, from computational imaging and spectroscopy to bioinformatics, neuroscience, and agriculture. In these areas, as well as in the development and application of new exascale systems such as Aurora, UChicago CS benefits from a strong partnership with Argonne National Laboratory.

Labs & Groups

Globus Labs

Ian Foster, Kyle Chard
Realizing a world in which all research data are reliably, rapidly, and securely accessible, discoverable, and usable.

Large-Scale Systems Group (LSSG)

Andrew A. Chien
Exploring critical systems research questions underlying sustainable, scalable large-scale systems, including cloud, high performance, edge, and mobile/IoT computing.

Chameleon

Kate Keahey, Haryadi Gunawi
A configurable experimental environment for large-scale edge to cloud research.

Center for Translational Data Science

Robert Grossman
A research center developing the discipline of translational data science and applying to advance biology, medicine, healthcare and environmental research.

Related Faculty

Kyle Chard

Kyle Chard

Research Associate Professor of Computer Science
Andrew A. Chien

Andrew A. Chien

William Eckhardt Distinguished Service Professor of Computer Science

Anshu Dubey

Senior Scientist, CASE Affiliate
Todd Dupont

Todd Dupont

Professor Emeritus of Computer Science, Mathematics, and the James Franck Institute
Ian Foster

Ian Foster

Arthur Holly Compton Distinguished Service Professor of Computer Science
Robert Grossman

Robert Grossman

Frederick H. Rawson Distinguished Service Professor in Medicine, Computer Science
Rana Hanocka

Rana Hanocka

Assistant Professor of Computer Science

Kate Keahey

Senior Scientist, CASE Affiliate
Gordon Kindlmann

Gordon Kindlmann

Associate Professor of Computer Science
Rick Stevens

Rick Stevens

Professor of Computer Science
Rebecca Willett

Rebecca Willett

Worah Family Professor in the Wallman Society of Fellows, Computer Science, Statistics, and the College

News & Events

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UChicago CS News

The Hidden Cost of Netflix’s Autoplay: A Study on Viewing Patterns and User Control

Feb 25, 2025
Raul Castro Fernandez
UChicago CS News

Raul Castro Fernandez among six UChicago scientists awarded prestigious Sloan Fellowships in 2025

Feb 18, 2025
UChicago CS News

Quantum Leap: New Research Reveals Secrets of Random Quantum Circuits

Feb 04, 2025
UChicago CS News

Fred Chong from the Department of Computer Science Named ACM Fellow for Contributions to Quantum Computing

Jan 22, 2025
UChicago CS News

Rethinking AI as a Thought Partner: Perspectives on Writing, Programming, and More

Jan 16, 2025
UChicago CS News

UChicago Partners On New National Science Foundation Large-Scale Research Infrastructure For Education

Dec 10, 2024
UChicago CS News

Saturdays with CSIL — How Undergraduates are Transforming CS Education for Local High School Students

Dec 05, 2024
UChicago CS News

UChicago Researchers Receive Google Privacy Faculty Award for Research on AI Privacy Risks

Nov 22, 2024
UChicago CS News

The Climate App Designed to Tackle Chatham’s Flooding Crisis

Nov 21, 2024
In the News

Globus Receives Multiple Honors in 2024 HPCwire Readers’ and Editors’ Choice Awards

Nov 20, 2024
In the News

Argonne Team Breaks New Ground in AI-Driven Protein Design

Nov 15, 2024
UChicago CS News

DOE Awards Fred Chong and his National Research Team $7.5M to Develop a SMART Software Stack to Control Quantum Computer Noise

Nov 12, 2024
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